Project: Pre-clinical imaging biomarkers of neurodevelopmental dysfunction in a mouse model of KCNQ2-developmental and epileptic encephalopathy
Project leader: Sarah Weckhuysen
VIB-Center for Molecular Neurology, University of Antwerp. Antwerp, Belgium
Project: Thermoception in murine neonates, a potential early life phenotypic marker of autism spectrum disorders
Project leader: Valery Matarazzo
INMED, INSERM UMR1249, Campus scientifique de Luminy, Aix-Marseille Universite. Marseille, France
Project: Persulfidome variations as a result of hydrogen sulfide dysregulation in DS: biological pathways alteration and therapeutic consequences
Project leader: Erwan Galardon
CNRS. Institut National de Chimie (INC). Villejuif, France
Project: Alterations of the DPP4/ DYRK1A/ GSK-3β axis are associated with intellectual disability and Alzheimer’s disease development in Down syndrome: search for novel therapeutic strategies
Project leader: Eugenio Barone
Sapienza University of Rome. Rome, Italy
Project: Exploring the role of circadian rhythms in CDKL5 deficiency disorder to discover novel therapeutic strategies
Project leader: Paola Tognini
University of Pisa. Pisa, Italy
Project: Elucidating the gene dosage effects of DYRK1A on Alzheimer’s disease pathology in mice: identification of biomarkers and pharmacological targets
Project leader: Marie-Claude Potier
Institut du Cerveau ICM. Paris, France
Project: Exploration of the nuclear roles of the Fragile-X Messenger RibonucleoProtein (FMRP) and their cross talk with its synaptic functions in mammalian neurons using multiple OMICs approaches
Project leader: Carole Gwizdek
Institut de Pharmacologie Moléculaire et Cellulaire. Valbonne, France
Project: Characterization of a novel Drosophila mutant overexpressing Mnb/Dyrk1A: a model system to study Down syndrome-Trisomy 21 neurobiological alterations and a possible platform for drug discovery
Project leader: Francisco J. Tejedor
Instituto de Neurociencias. CSIC & UMH. Alicante, Spain
Project: DS Biome – Investigating Down Syndrome Gut Microbiome
Project leader: Paul Cotter
Teagasc Food Research Centre. Fermoy, Ireland
Project: Assessment and predictors of Alzheimer’s disease in Down syndrome across language groups and countries
Project leader: Andre Strydom
King’s College London. London, United Kingdom