Grants: Autumn 2022 Selected Projects

18 novembre 2022

Within the framework of the Jérôme Lejeune Foundation Grants programme, we are pleased to announce the projects selected in the Autumn 2022 call for grants, which targeted research on Down syndrome.

6 projects were selected from the 25 applications received on Down syndrome. This represents a selection rate of 24%.

Exceptionally, 4 out of 12 projects on other intellectual disabilities that were invited to resubmit due to their high quality, were also validated in this call.

The overall budget validated for this call was of 557.025 €.

Project: Pre-clinical imaging biomarkers of neurodevelopmental dysfunction in a mouse model of KCNQ2-developmental and epileptic encephalopathy
Project leader: Sarah Weckhuysen
VIB-Center for Molecular Neurology, University of Antwerp. Antwerp, Belgium

Project: Thermoception in murine neonates, a potential early life phenotypic marker of autism spectrum disorders
Project leader: Valery Matarazzo
INMED, INSERM UMR1249, Campus scientifique de Luminy, Aix-Marseille Universite. Marseille, France

Project: Persulfidome variations as a result of hydrogen sulfide dysregulation in DS: biological pathways alteration and therapeutic consequences
Project leader: Erwan Galardon
CNRS. Institut National de Chimie (INC). Villejuif, France

Project: Alterations of the DPP4/ DYRK1A/ GSK-3β axis are associated with intellectual disability and Alzheimer’s disease development in Down syndrome: search for novel therapeutic strategies
Project leader: Eugenio Barone
Sapienza University of Rome. Rome, Italy

Project: Exploring the role of circadian rhythms in CDKL5 deficiency disorder to discover novel therapeutic strategies
Project leader: Paola Tognini
University of Pisa. Pisa, Italy

Project: Elucidating the gene dosage effects of DYRK1A on Alzheimer’s disease pathology in mice: identification of biomarkers and pharmacological targets
Project leader: Marie-Claude Potier
Institut du Cerveau ICM. Paris, France

Project: Exploration of the nuclear roles of the Fragile-X Messenger RibonucleoProtein (FMRP) and their cross talk with its synaptic functions in mammalian neurons using multiple OMICs approaches
Project leader: Carole Gwizdek
Institut de Pharmacologie Moléculaire et Cellulaire. Valbonne, France

Project: Characterization of a novel Drosophila mutant overexpressing Mnb/Dyrk1A: a model system to study Down syndrome-Trisomy 21 neurobiological alterations and a possible platform for drug discovery
Project leader: Francisco J. Tejedor
Instituto de Neurociencias. CSIC & UMH. Alicante, Spain

Project: DS Biome – Investigating Down Syndrome Gut Microbiome
Project leader: Paul Cotter
Teagasc Food Research Centre. Fermoy, Ireland

Project: Assessment and predictors of Alzheimer’s disease in Down syndrome across language groups and countries
Project leader: Andre Strydom
King’s College London. London, United Kingdom