Grants: Spring 2022 Selected Projects
Within the framework of the Jérôme Lejeune Foundation Grants programme, we are pleased to announce the projects selected in the Spring 2022 call for grants, which targeted research on Down syndrome and other intellectual disabilities from genetic origin.
11 projects were selected from the 72 applications received. This represents a selection rate of 15% and an overall budget of €503.000.
List of selected projects:
Project: Lactococcus Lactis As Promising Live Vector For The Safe Delivery Of Secretable Tatk-Cdkl5 Protein In Treatment Of Cdkl5 Deficiency Disorder
Project leader: Ciani Elisabetta
University of Bologna. Bologna, Italy
Project: Understanding the Cellular Mechanisms of the 1q21.1 Neurodevelopmental Disorder
Project leader: Murielle Saade
Institut de Biologia Molecular de Barcelona- CSIC. Barcelona, Spain
Project: Role of neuropeptides on Blood Brain Barrier formation and maintenance in a 22q11.2DS mouse model
Project leader: Bice Chini
Istituto di Neuroscienze. Consiglio Nazionale delle Ricerche. Rome, Italy
Project: Abnormal astrocyte morphology and cytoskeleton in the brain impairment of myotonic dystrophy
Project leader: Mario Gomes-Pereira
Centre de Recherche en Myologie – Inserm UMRS 974. Paris, France
Project: Investigating Down syndrome related diabetes with a human trisomy 21 iPSC disease model
Project leader: Barak Blum
University of Wisconsin – Madison. Madison (WI), USA
Project: TOTORO: Transcranial Direct current stimulatiOn (tDCS) as a Treatment for depressiOn with catatonic features in patients with Down’s syndROme: a pilot randomised control study
Project leader: Jerome Brunelin
Centre de Recherche en Neurosciences de Lyon, Inserm U1028, CNRS UMR5292, Centre Hospitalier Le Vinatier. Bron, France
Project: DGKk loss of function as a novel cause of intellectual disability
Project leader: Hervé Moine
Institut de Génétique et Biologie Moléculaire et Cellulaire (IGBMC). Illkirch, France
Project: Understanding the physiopathological mechanisms underlying the cerebral malformations and intellectual deficiency associated to RNU4ATAC-related syndromes
Project leader: Marion Delous
Centre de Recherche en Neurosciences de Lyon, Inserm U1028, CNRS UMR5292, Université Claude Bernard Lyon1. Bron, France
Project: Impaired response to cellular stress and astrocytic senescence in Fragile X syndrome: an explorative in vitro and ex vivo study.
Project leader: Maria Vincenza Catania
Institute for Biomedical Research and Innovation – National Research Council (IRIB-CNR). Catania, Italy
Project: New insight into molecular pathogenic mechanisms of PAK3 mutations analysed using a large mutation cohort and a new mouse model
Project leader: Jean-Vianney Barnier
Institut des neurosciences Paris-Saclay, UMR9197. Saclay, France
Project leader: Analysis of the proteome and behavioural responses to the HDACi Vorinostat in Arx mouse model of developmental epileptic encephalopathy
Project leader: Maria Giuseppina Miano
Institute of Genetics and Biophysics Adriano Buzzati-Traverso – National Research Council (CNR). Naples, Italy